Gene name:
Ccdc109b (Mcub) ;
Protein name:
Mitochondrial calcium uniporter regulatory subunit MCUb (MCUb) ;
Alternative:
Coiled-coil domain-containing protein 109B ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (By similarity). Heterotetramer with MCU; this reduces MCU channel activity. Homooligomer.
Function:
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Subcellular Location:
Mitochondrion inner membrane
Multi-pass membrane protein
Mitochondrion
Protein Attributes:
50:
MPGALSGRRM | LPSGLCLGRW | QLLRTIRARG | RGDPRELPST | PQVLCMKLYG |
100:
NPKYHQALHY | GTVEPQDEIT | VTYKHGLPLV | TLTLPSRKER | CQFVVKPMLS |
150:
TVGSFLQDLQ | NEDKGIKTAA | IITADGSEIP | ASTLMDTLLM | TDFKLIINKL |
200:
RYDIRCHKKE | EPSGEHMTEL | ENTKSLVHRL | FTILHLEEIQ | KRRERHLMAK |
250:
IDHLQEQLRP | LEQVKAAIEA | RSEANTSGLL | WAGLALLSVQ | GGALAWLTWW |
300:
VYSWDIMEPV | TFFLSFANSI | VFFAYFIITR | QNYTYSSLRS | RQFLQFFHKK |
345:
SQRRCFDVEQ | YNKLKEDLAE | ATESLESVRR | SLRLRIQGEE | ASEKN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Human
Mouse
Mouse
Polyclonal Antibody for Mouse MCUb
Polyclonal Antibody for Mouse MCUb
Polyclonal Antibody for Mouse MCUb
Polyclonal Antibody for Mouse MCUb
Monoclonal Antibody for Mouse MCUb
Monoclonal Antibody for Mouse MCUb
Monoclonal Antibody for Mouse MCUb
Monoclonal Antibody for Mouse MCUb
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Bone marrow .
tissue :
Colon .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT;INTERACTION WITH MCU;SUBCELLULAR LOCATION;TISSUE SPECIFICITY